MESOTHELIOMA

MESOTHELIOMA
For those diagnosed with mesothelioma, an asbestos-related cancer of the lining of the lung (pleura) or the lining of the abdominal cavity (peritoneum), finding a credible source of information about the disease itself and the medical options available, is of the highest priority. After years of research and synthesis of information, we have assembled a web site and packet for patients and their loved ones. We hope you find this web site helpful.

A mesothelioma diagnosis can be overwhelming, and we are here to answer any questions you might have, and to help you take the steps necessary to find the options that are best suited to your individual needs.

Our staff is experienced and knowledgeable in dealing with mesothelioma patients and their family members, and the service we provide is always with appreciation for the difficult time you are facing. Although you have found us on the Internet, rest assured there are real people here to help. Please feel free to contact us at any time at 1-877-FOR-MESO (367-6376). (Please read disclaimer at bottom of page before proceeding.)

HOPE
"Hope is the companion of power, and the mother of success; for who so hopes strongly, has within him the gift of miracles." -- Samuel Smiles

This segment begins with more information about malignant mesothelioma, including the causes of the disease and characteristic symptoms. Our comprehensive section on mesothelioma treatment options discusses surgery, chemotherapy, and radiation therapy as well as new types under investigation. We discuss ways to find specialists who treat mesothelioma and some advice on choosing your doctor . The Clinical Trials segment details current clinical studies and links to information specific to those trials.

SUPPORT
"Too often we understimate the power of a touch, a smile, a kind word, a listening ear, an honest compliment, or the smallest act of caring, all of which have the potential to turn a life around." --Dr. Leo Buscaglia

Start planning with Comprehensive Cancer Centers, how to find places to stay near treatment facilities and how to get there in the Travel & Lodging section. Relevant medical journal and mesothelioma news articles are updated regularly. Our SUPPORT segment ends with Survivors & Fighters who have uplifting stories to tell.

HELP
"Knowledge is power."-Francis Bacon

This segment provides Leading Cancer Links. In Your Peace of Mind you’ll find resources to help you and your family feel secure in the weeks, months and years ahead. Here you can find links to information on financial assistance, compensation, and legal options.

NEW: A clinical trial for a lung-sparing combined modality protocol is recruiting mesothelioma patients.

You will probably want to come back to this site in the future, so remember to bookmark this page. For instructions on how to bookmark, click here.

Jurors Hear Closing Arguments in Grace Case
Lawyers from both sides presented their closing arguments Wednesday as the W.R. Grace & Co. trial comes to a close.

The prosecution began their closing arguments when Assistant U.S. Attorney Kris McLean opened by covering the conspiracy charges while attorney Kevin Cassidy concluded by reviewing the charges of knowing endangerment and obstruction of justice.

McLean covered around 50 documents from 1972 to 2003 that he argued were examples of Grace putting profits over safety.

Next defense attorney David Bernick argued that the government had a flawed case and had taken the EPA's script and rewritten it into a case. Bernick used a white board and charts to reiterate his argument that the government had no case against the executives.

Earlier in the day, Judge Donald Molloy presented more than 50 instructions to the jury and defined terms that had been used throughout the trial. Molloy instructed jurors not to consider the testimony of Robert Locke whose testimony became a heated issue after it was discovered he may have contradicted himself.

In addition Molloy instructed jurors not to use part of the testimony from Dr. Alan Whitehouse. He instructed jurors to disregard testimony related to his asbestos predictions but to consider the rest of his testimony. Dr. Whitehouse is a pulmonologist who has treated many former Grace employees.

Diagnosis

Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history. A history of exposure to asbestos may increase clinical suspicion for mesothelioma. A physical examination is performed, followed by chest X-ray and often lung function tests. The X-ray may reveal pleural thickening commonly seen after asbestos exposure and increases suspicion of mesothelioma. A CT (or CAT) scan or an MRI is usually performed. If a large amount of fluid is present, abnormal cells may be detected by cytology if this fluid is aspirated with a syringe. For pleural fluid this is done by a pleural tap or chest drain, in ascites with an paracentesis or ascitic drain and in a pericardial effusion with pericardiocentesis. While absence of malignant cells on cytology does not completely exclude mesothelioma, it makes it much more unlikely, especially if an alternative diagnosis can be made (e.g. tuberculosis, heart failure).

If cytology is positive or a plaque is regarded as suspicious, a biopsy is needed to confirm a diagnosis of mesothelioma. A doctor removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples.

If the cancer is in the abdomen, the doctor may perform a laparoscopy. To obtain tissue for examination, the doctor makes a small incision in the abdomen and inserts a special instrument into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.

Signs and symptoms

Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.

Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity). Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.

These symptoms may be caused by mesothelioma or by other, less serious conditions.

Mesothelioma that affects the pleura can cause these signs and symptoms:

chest wall pain
pleural effusion, or fluid surrounding the lung
shortness of breath
fatigue or anemia
wheezing, hoarseness, or cough
blood in the sputum (fluid) coughed up (hemoptysis)
In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread, to other parts of the body.

Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:

abdominal pain
ascites, or an abnormal buildup of fluid in the abdomen
a mass in the abdomen
problems with bowel function
weight loss
In severe cases of the disease, the following signs and symptoms may be present:

blood clots in the veins, which may cause thrombophlebitis
disseminated intravascular coagulation, a disorder causing severe bleeding in many body organs
jaundice, or yellowing of the eyes and skin
low blood sugar level
pleural effusion
pulmonary emboli, or blood clots in the arteries of the lungs
severe ascites
A mesothelioma does not usually spread to the bone, brain, or adrenal glands. Pleural tumors are usually found only on one side of the lungs.

Mesothelioma

Mesothelioma is a form of cancer that is almost always caused by exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and internal chest wall), but it may also occur in the peritoneum (the lining of the abdominal cavity), the heart,[1] the pericardium (a sac that surrounds the heart) or tunica vaginalis.

Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma.[2] Unlike lung cancer, there is no association between mesothelioma and smoking, but smoking greatly increases risk of other asbestos induced cancer.[3] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see asbestos and the law).

The symptoms of mesothelioma include shortness of breath due to pleural effusion (fluid between the lung and the chest wall) or chest wall pain, and general symptoms such as weight loss. The diagnosis may be suspected with chest X-ray and CT scan, and is confirmed with a biopsy (tissue sample) and microscopic examination. A thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as talc to obliterate the pleural space (called pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with chemotherapy, radiation therapy or sometimes surgery, the disease carries a poor prognosis. Research about screening tests for the early detection of mesothelioma is ongoing.